South Africa is one of the five countries where the ASCENT project was implemented. A total of 64 health care facilities in the Gauteng Province- Tshwane District and Western Cape Province- West Coast District participated in the project. Participants and health care workers made use of digital adherence technologies to support people taking their TB treatment at home. The first participants were be enrolled in October 2021. The project reached the participation of 3,084 people with TB in South Africa.

South Africa has a population of 58 million people and is one of the 30 high burden TB countries in the world, as listed by the World Health Organization (WHO). According to the WHO in 2018 an estimated 301,000 people suffered from TB in South Africa, making the TB incidence rate 520 per 100,000 people. An estimated 11,000 people suffered from multidrug resistant TB. The WHO estimates 63,000 people died of TB in South Africa in 2018.